منابع مشابه
SOS1 expression in Salicornia
The plasma membrane Na + /H + -antiporter SOS1 is essential for salt tolerance in plants. In Chapter 4, we observed a ten-fold higher constitutive expression of SOS1 in the highly salt tolerant salt-accumulating halophyte Salicornia dolichostachya in comparison with a lower inducible SOS1 expression in its glycophytic family member Spinacia oleracea. The objective of this study was to investiga...
متن کاملCharacterization of GRB2 and SOS1 binding downstream of TCR activation
Despite their essential role in protection, T cells can be dangerous if unregulated. Dysfunctional T cell activity has been implicated in numerous diseases, including the failure of organ transplants, allergic reactions, multiple sclerosis, and coronary artery disease. Signal transduction pathways activated by the T cell receptor (TCR) are good targets for the development of therapies. However,...
متن کاملBranch-and-cut for linear programs with overlapping SOS1 constraints
SOS1 constraints require that at most one of a given set of variables is nonzero. In this article, we investigate a branch-and-cut algorithm to solve linear programs with SOS1 constraints. We focus on the case in which the SOS1 constraints overlap. The corresponding conflict graph can algorithmically be exploited, for instance, for improved branching rules, preprocessing, primal heuristics, and...
متن کاملSos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity.
Podosomes are protrusive structures implicated in macrophage extracellular matrix degradation and three-dimensional migration through cell barriers and the interstitium. Podosome formation and assembly are regulated by cytoskeleton remodeling requiring cytoplasmic tyrosine kinases of the Src and the Abl families. Considering that Abl has been reported to phosphorylate the guanine nucleotide exc...
متن کاملDirect inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices.
Activating mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) underlie the pathogenesis and chemoresistance of ∼ 30% of all human tumors, yet the development of high-affinity inhibitors that target the broad range of KRAS mutants remains a formidable challenge. Here, we report the development and validation of stabilized alpha helices of son of sevenless 1 (SAH-SOS1) as prototyp...
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ژورنال
عنوان ژورنال: Plant Signaling & Behavior
سال: 2009
ISSN: 1559-2324
DOI: 10.4161/psb.4.11.9786